منابع مشابه
Shaping chromatin with DICER
The accessibility of chromatin is an essential feature of DNA templated processes such as DNA replication, transcription and DNA repair. The chromatin condensation state, and thus accessibility, is modulated by a variety of chromatin remodeling complexes [1] as well as epigenetic components; for instance by bridging gene regulatory elements [2]. More recently, the function of ncRNAs in regulati...
متن کاملDicer Is Associated with Ribosomal DNA Chromatin in Mammalian Cells
BACKGROUND RNA silencing is a common term for pathways utilizing small RNAs as sequence-specific guides to repress gene expression. Components of the RNA silencing machinery are involved in different aspects of chromatin function in numerous organisms. However, association of RNA silencing with chromatin in mammalian cells remains unclear. METHODOLOGY/PRINCIPAL FINDINGS Immunostaining of mito...
متن کاملShaping the landscape: mechanistic consequences of ubiquitin modification of chromatin.
The organization of eukaryotic chromosomes into transcriptionally active euchromatin and repressed heterochromatin requires mechanisms that establish, maintain and distinguish these canonical chromatin domains. Post-translational modifications are fundamental in these processes. Monoubiquitylation of histones was discovered more than three decades ago, but its precise function has been enigmati...
متن کاملDICER and ZRF1 contribute to chromatin decondensation during nucleotide excision repair
Repair of damaged DNA relies on the recruitment of DNA repair factors in a well orchestrated manner. As a prerequisite, the chromatin needs to be decondensed by chromatin remodelers to allow for binding of repair factors and for DNA repair to occur. Recent studies have implicated members of the SWI/SNF and INO80 families as well as PARP1 in nucleotide excision repair (NER). In this study, we re...
متن کاملChromatin Changes in Dicer-Deficient Mouse Embryonic Stem Cells in Response to Retinoic Acid Induced Differentiation
Loss of Dicer, an enzyme critical for microRNA biogenesis, results in lethality due to a block in mouse embryonic stem cell (mES) differentiation. Using ChIP-Seq we found increased H3K9me2 at over 900 CpG islands in the Dicer(-/-)ES epigenome. Gene ontology analysis revealed that promoters of chromatin regulators to be among the most impacted by increased CpG island H3K9me2 in ES (Dicer(-/-)). ...
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ژورنال
عنوان ژورنال: Oncotarget
سال: 2017
ISSN: 1949-2553
DOI: 10.18632/oncotarget.17773